They may sell for better prices, but you need high volume as well.
Why sell 10 mods per day at a 1mil profit each in a lvl 4 agent station when I could sell 60 at 200k profit each in a hub and not need to do the extra hauling.

You can only sell in the smaller markets effectively with high trade skills (you need to place more orders+ be able to modify them at range) as you need to spread where your orders are as well as deal with the logistics of having your wares spread across more stations to cope with the lower volumes.

As a missioner I'd by single mods (e.g. I'd just lost a drone or two due to disconnect) in station if I needed it, but I'd buy ships+ full fittings at the hub, as the savings and guaranteed stock are a huge convenience.

Not true at all. I've been helping a friend do Tech 1 Manufacturer for the past couple weeks and he only has it at 4 and he is making profit. You only look at 200 items? Keep looking.

Aluka has mentioned a few in this very thread that are indeed (still) profitable. You do not need it at 5, does it help? Of course, but telling a new player they absolutely need it at 5 to make any profit is absorb. I've been here from 2003 almost solely manufacturing/inventing/r&d so I know this like the back of my hand.

Finally someone that is actually manufacturing items with "normal margin" and can confirm that there are profitable items in T1 production even with lower prod. eff.
I'm still looking @ items in my production queue that have >100% margin with bought raw materials and I'm like WHHAATTT?.

For the more serious manufacturers, it's not about the margin though. It's about profit per hour. I'm not saying that the items you're building aren't good. But the fact is that you can build ammo with a profit margin of 100% and make 500k ISK per day, and then you can build something else with a profit margin of 2% and make 10 million per day instead.

Blue, production efficiency directly affects size of the margin and that is why I have only mentioned that in my last post.
In original (first) post under "Very important detail" title, I go into details that profit per hour (or per day that I use) is more important than margin like you excellently pointed out.
That is why skills that speed up production and P.E. research of BPO are important almost the same as M.E research and production eff.. But everyone focuses only on prod. eff. skill for some reason :)

P.S. My aim is >5-10mil/day per production line (depending on additional logistic work).

Blue, production efficiency directly affects size of the margin and that is why I have only mentioned that in my last post.
In original (first) post under "Very important detail" title, I go into details that profit per hour (or per day that I use) is more important than margin like you excellently pointed out.
That is why skills that speed up production and P.E. research of BPO are important almost the same as M.E research and production eff.. But everyone focuses only on prod. eff. skill for some reason :)

P.S. My aim is >5-10mil/day per production line (depending on additional logistic work).

I'd like to note that without Production Efficiency at lvl 4 it's impossible to make a profit on anything T1, or at least any of the 200+ items I've looked at. Even with PE at 4, you're still looking at around only ~%20 profit listing at current sell prices, so any impressive ISK/hour is going to require a massive amount of start up capital.

This is patently false (unless you, for some reason, insist on selling in Jita, Amarr, or Dodixie). It's quite easy to make profit on a wide range of T1 items in markets where you don't have to slash prices to sell. As I said before, KNOW YOUR MARKETS. If anyone has trouble honestly understanding this concept, there are plenty of threads out there on it. If you want the Easy Button answer, start a new thread about such, and you're bound to get VERY helpful pointers on exactly how to find, analyze, and market your stuff.

If you want to get ahead, you need to understand and seperate your profit by category; your manufacturing profit is what you can make buying from a sell order, manufacturing, and selling to a buy order. All the rest is not actually manufacturing profit. If your making trade profit, it can often be more profitable to resell without manufacturing at all

Since I am new to manufacturing (wholesale trader / reseller mostly) I would like to know if its worth the time and effort to set up a POS. If it should be in high or low sec, or wormhole space ( for safety) and how that would affect manufacturing. Basically what are the great advantages of a POS over a station since you need to pay upfront costs and fuel, and how if effects profit margin. And are reactions worth it doing?

Also what are the main mission areas that would be good to sell manufactured stuff near (even though this is more of a shipping / trading profit matter)?

Would it be more worth while set up a manufacturing in an area you wish to sell ( ship in or buy minerals or ore locally ) and eliminate the need of shipping of finished products (from jita area) to a higher profit area?

Any suggestions on making your spreadsheets which is essencial I've found? Is there someplace that you can get manufacturing minerals required list per item to copy / paste into them, or is there some manufacturing mineral checking program or something :P