At any rate, the OP is a thinly veiled attempt to have CCP change the system. Why you ask, well here's why:

1.The suggestions in this thread are well known, borderline common knowledge.
2. The OP isn't popping his forum cherry right now, he's seen all this before.
3. This is his third thread on the same topic, the other two have been locked, recently.
4. He was precise in his wording, he wants to "nullify" hi sec freighter ganking, not "mitigate", not "reduce", not "make less frequent or more difficult or more expensive", he simply wants to nullify freighter ganking. (see definition below before you try to further mince words)

(nullify [-ên-îl+¬-îfa+¬]
vb -fies, -fying, -fied (tr)
1. (Law) to render legally void or of no effect
2. to render ineffective or useless; cancel out)

5. In order to make ganking ineffective, useless, or cancel it out...in otherwords to nullify it, you WOULD in fact have to change gameplay mechanics, as currently ganking is "possible" by definition.

TL;DR Yes, yes the OP is in fact "looking to CCP to change the system"

Resistance is futile....

At least that's what the Gankers want you to think.

CCP know using autopilot isn't what it used to be. They do nothing.

Thank you for that. I was not aware that the OP was anything other than a noob who wanted some advice.

Firstly, I feel that almost (euphemism) every single thread started in GD with a view to getting help is utterly flamed, no matter the experience of the individual who started it. You all talk about EVE taking your cookie and laughing at you. Very well, but it would be nice if those asking for assistance were given some. Maybe let's take their cookie and pat them on the head for thinking they could have a cookie? That's all.

Secondly, yes, the OP needs to do some googling and research etc, but one would rather expect the EVE forums to be a good place to ask for ideas.

Thirdly, I rather read the OP's post as being 'how can I reduce the threat of being ganked' rather than 'nullify'. Men have a way of being overdramatic in their use of vocab. But then ASS-U-ME & etc. But thank you for the provision of a definition.

I am afraid that this thread and its responses rather saw the blunt end of my indignance as I am somewhat fed up of GD threads being the same old 'What if/How do I/What do I need to do if....' and 'STFU Carebear/Null-seccers suck/Hi-seccers suck/if you don't know what to do then you should BURRRRRRRRRRRRRRRRN.'

Thirdly, I rather read the OP's post as being 'how can I reduce the threat of being ganked' rather than 'nullify'. Men have a way of being overdramatic in their use of vocab. But then ASS-U-ME & etc. But thank you for the provision of a definition.

I never said that Incursion runners would be the ones to do it.
I am talking about that level of co-ordination.

Whether there are people willing to do this, that is indeed the question.

I don't side with the gankers, nor do I side with fools who fly around with 50 plex's in cargo.

I'm a man, and consider your accusations to be mildly sexist. Beyond that, you suggested that you "interpreted" the OP to mean mitigate, as opposed to nullify. He bluntly uses the word nullify in the thread title. So, I am not "assuming" anything, simply pointing out "specifically" what he "said".

You know you can also roll fat freighters with a T3 boosting alt, which would raise EHP to such a significant degree that it might break most gank attempts, right?

Can anyone open EFT and compare frighter EHP, at full level 5 skills, with and without the following: 5% shield/armor/hull hardwirings, a fully-skilled, mindlinked Legion booster with the armor resist link and the shield resist link, and maybe a slave set? If no one does it, I'll do it by hand, but I'm a bit busy atm.

Faulting a freighter for carrying to much is like faulting someone who is carrying a briefcase full of money in an area with tons of police ready at any moment.

Cops should be able to insta pod a gankers head.

This sounds almost exactly like a recent discussion that took place over mining barges.

Do you think CCP will make the same assumption, that freighter pilots are too stupid to fly their ships without help?

3. Not cramming your freighter to the brim with PLEX/Officer mods in the first place

Has anyone realized that you don't actually need to use a freighter to haul plex?

I mean the key reason to stupidity here is that you can purchase and redeem plex on any character on any account.

I have been struggling with tactics to neutralize freighter ganking in high sec but unfortunately, I can't envision any.
Most of the gankers are already insta-targets now in high sec, and no one has been able to mount a decent defense.
And I don't see any changes to that fact with the new game mechanics.
In fact, it will be worse.

Is there anyone out there that thinks they have tactics that will work in 2 weeks?

I think the other 2 got locked because of comments on the thread from people other than the OP. Thats what ISD's do; lock threads that have too many naughty comments in them. Thats their JOB.

I have a visceral hatred of the sociopaths in this game.

I have been struggling with tactics to blow these asshats out of the sky

Most of these creeps are already insta-targets now in high sec

The rest of the carebears have already figured out the perfect tactic. They'll throw their lil tantrums on the forums, threaten to unsub and demand that the game is changed to suit their AFK, no-effort playstyle. Trying to game the system and beat the gankers is too much effort - they'd have to pause Netflix and alt tab into the game.

@ Destiny, didn't sound like whining to me, sounded like he just wanted some helpful suggestions on how to deal with it. Sounds like you are the one whining that yet another individual has come to the forums for assistance and they must clearly be looking to CCP to change the system. Not because they just wanted realistic suggestions on what to do, eg take small support fleet etc

But thank you for your incredibly helpful reply which has obviously assisted GD with reaching its dailly quota of douchebag

Actually one of them was locked because you're not allowed to reopen locked threads by recreating the OP, which is what OP has done here.

Add Uedama and Niarja to your avoidance list and make a route going anywhere. See the problem?

Put cans of junk in your cargo hold. The list becomes so long they don't read it.